Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- ReviewReview Article Published on 2022-12-152022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] accumulating biogenesis Cell cell stress concerning coronavirus disease Coronavirus infections COVID-19 DDR disrupt DNA damage Effect endotheliopathy eukaryotic cells Evidence Focusing function gene silencing Human human diseases MINI nucleoli Nucleolopathy Nucleolus nucleus organism Organisms pathogenic precursor Protein provided Regulation Replication review subcellular tRNA viral infection viral infections virus [DOI] 10.30699/IJP.2021.540305.2744 PMC 바로가기 [Article Type] Review Article
Intestinal Infarction in COVID-19 Pandemic: A Case SeriesOriginal Article Published on 2022-11-072022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] Abdominal CT Scan blood flow Clinical data coagulation disorder collected Complication coronavirus coronavirus disease COVID-19 described digestive system disrupt events Evidence headache Health Imam include Infection infection process intestinal Iran Ischemia Mashhad Medical Sciences mesenteric ischemia Necrosis novel operative organs pathological finding Patient patients hospitalized physician reported respiratory symptoms Reza risk factor Sery severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia Spread suggested Symptom thrombosis university Vascular visceral with COVID-19 [DOI] 10.30699/IJP.2021.525280.2600 PMC 바로가기 [Article Type] Original Article
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
Genome-wide detection of human variants that disrupt intronic branchpointsArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] Alter approach branchpoint Candidates characterized comparable COVID-19 Critical database demonstrated detect disease Disease genetics disrupt disrupting eight elements enzyme exonic feature heterozygous human gene human population identify initiated intron Intronic intronic variant ITPKB lymphoma machine-learning motif nucleotides upstream pathogenic Patient Pneumonia rare variant reported RNA sequencing RNA splicing sequencing data single-nucleotide Software splicing. STAT2 utility variant variants Variation [DOI] 10.1073/pnas.2211194119 PMC 바로가기
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling PathwayArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus [DOI] 10.1128/spectrum.02322-22 PMC 바로가기
Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain InhibitorsArticle Published on 2022-10-202022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Algorithm Alpha variant bind binding binding affinity candidate caused Concentration concentrations COVID-19 pandemic demonstrated disrupt domain ELISA assays entry of SARS-CoV-2 experiments expressed globe host cells human cells inhibitory initial insoluble Interaction moderate Molecular dynamics simulation molecule peptidase peptide Prevent Protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2-RBD sequence spike the RBD the SARS-CoV-2 therapeutic These data validation variants virus entry was used Wuhan-Hu-1 α1 helix [DOI] 10.1021/acs.jpcb.2c03918 PMC 바로가기
Griseofulvin: An Updated Overview of Old and Current KnowledgeArticle Published on 2022-10-182022-11-16 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] ACE2 addition ascomycetes binding cancer cell capillary blood flow Cell contribute current derivative dermatophytic fungi disrupt domain Drug repurposing ENhance explain FDA-approved drug filament protein griseofulvin griseofulvin derivatives gsf gene cluster Hepatitis hepatitis C virus hepatocyte IMPROVE infections information inhibitory effect Inhibitory effects Interaction introduced K18 Liver injury Mallory mechanism metabolite metabolites mitosis molecular docking analysis multifunctional polyketide compound produced RBD RdRP Replication responsible RNA-dependent RNA polymerase rodent SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 main protease severity Spike protein spindle microtubule. therapeutic interventions treated Vascular viral replication [DOI] 10.3390/molecules27207034 PMC 바로가기
Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine stormArticle Published on 2022-10-102022-11-16 Journal: NPJ Systems Biology and Applications [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute respiratory distress agonists Antimicrobials approach approved drugs automated biological pathway candidate drug Combination competing complex Compound compounds COVID-19 infection Cytokine storm Dexamethasone disrupt downstream interaction driving drug drug combination Drug discovery drugs drugs targeting dysregulation Effects element engage functional Host host immune system identify immune in silico Approach Interaction Intervention less mTOR inhibitor other disease peer-reviewed predicted Regulatory scored signaling cascade significantly subset suppressor syndrome target while [DOI] 10.1038/s41540-022-00250-9 PMC 바로가기
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitopeArticle Published on 2022-10-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody binding Antibody Response association competing cryo-EM Delta delta variant disrupt elicit epitope evade host immune responses hydrophobic immune evasion immune response impair inhibiting Interaction L452R Lineage mechanism Mutation neutralization omicron Population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike receptor-binding domain spike variants Spread Substitution substitutions target thought variant virus entry virus variants [DOI] 10.1038/s41564-022-01235-4 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기